1520 – The Smallpox – The Aztec Empire was destroyed by a smallpox infection brought in by African slaves.

1620 – The Pestilence or The Pest – It cost the lives of 30,000 to 50,000 inhabitants of Algiers in 1620-1621

1720 – The Great Plague of Marseille – this was the last significant European outbreak of the bubonic plague. It killed a total of 100,000 people in the city of Marseille, France.

1820 – The First Cholera Pandemic – By 1820, cholera had spread to Thailand, Indonesia, and the Philippines. On the island of Java alone, the outbreak caused the death of 100,000 people.

1920 – The Spanish Flu – In 1918-1920, the world was faced with the influenza pandemic. It would be the first of two pandemics to involve the H1N1 influenza virus - “avian influenza” or bird flu. The virus had a massive reach, infecting 500 million people around the world. According to Wikipedia, the death toll worldwide was up to 100 million, making it one of the deadliest in human history.

But not as deadly as

"The Black Death"

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